# Reading list

> Biohack Factory reading list — The Biohack Factory reading list gathers AOD-9604 metabolic experiments, oral human tolerability, rabbit cartilage work and broader safety reviews.

AOD-9604 reports, arranged around the jobs being tested.

## Fat metabolism and the human report

For the fragment’s experimental identity, start with the [metabolic-domain study](https://pubmed.ncbi.nlm.nih.gov/11146367/). The [earlier rat fat-pad paper](https://pubmed.ncbi.nlm.nih.gov/8358331/) concerns a related C-terminal sequence, while the [receptor-knockout mouse paper](https://pubmed.ncbi.nlm.nih.gov/11713213/) examines AOD9604 itself.

The [oral human safety report](https://www.jofem.org/index.php/jofem/article/view/157/194) concerns tolerability. For sheer experimental texture, the mouse paper is my first choice, with its split between acute and chronic responses.

## Publication years and experimental settings

The dates below are publication years: the [rat-tissue fragment study](https://pubmed.ncbi.nlm.nih.gov/8358331/), the [AOD9604 mouse experiment](https://pubmed.ncbi.nlm.nih.gov/11713213/), the [human tolerability report](https://www.jofem.org/index.php/jofem/article/view/157/194) and the [rabbit cartilage study](https://pubmed.ncbi.nlm.nih.gov/26275694/). They mark different questions, rather than successive levels of a single completed test.

![A horizontal timeline marks publication years for rat tissue, mouse, human tolerability and rabbit cartilage reports.](images/publication-years.svg)

*Publication years of the linked reports; the earlier rat-tissue work concerns a related growth-hormone fragment.*

## Cartilage and broader safety

The [rabbit knee study](https://pubmed.ncbi.nlm.nih.gov/26275694/) is the direct cartilage experiment discussed here. For a broader caution about peptide therapies, there is the [sports-medicine safety and efficacy review](https://pubmed.ncbi.nlm.nih.gov/41966639/).

## References

[1] Metabolic studies of a synthetic lipolytic domain (AOD9604) of human growth hormone https://pubmed.ncbi.nlm.nih.gov/11146367/
[2] Antilipogenic action of synthetic C-terminal sequence 177-191 of human growth hormone https://pubmed.ncbi.nlm.nih.gov/8358331/
[3] The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and beta(3)-AR knock-out mice https://pubmed.ncbi.nlm.nih.gov/11713213/
[4] Safety and Tolerability of the Hexadecapeptide AOD9604 in Humans https://www.jofem.org/index.php/jofem/article/view/157/194
[5] Effect of Intra-articular Injection of AOD9604 with or without Hyaluronic Acid in Rabbit Osteoarthritis Model https://pubmed.ncbi.nlm.nih.gov/26275694/
[6] Safety and Efficacy of Approved and Unapproved Peptide Therapies for Musculoskeletal Injuries and Athletic Performance https://pubmed.ncbi.nlm.nih.gov/41966639/

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Biohack Factory houses my arguments with published research about biological shortcuts; it does no business and supplies no medical advice.